Squamous cell carcinoma of the neovagina 47 years after gender-affirming surgery

Squamous cell carcinoma of the neovagina 47 years after gender-affirming surgery

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A 74-year-old transgender female presented with urinary difficulty and a painful lesion at her neo-vagina, 47 years after undergoing gender-affirming vaginoplasty.Initial biopsy reported Low-Grade Squamous Intraepithelial Lesion (LGSIL), while MRI revealed no inguinal or pelvic lymphadenopathy.Patient underwent partial neo-vaginectomy with wide local excision Business Card Scanner and formal urethroplasty.

Pathology revealed verrucous carcinoma of the neovagina, a rare Horizontal Rectangle Wooden Plaque neoplasm in transgender female patients.This case highlights the importance of considering squamous cell carcinoma in the differential diagnosis of patients presenting lesions at neo-vagina and the need of screening methods for early detection of such neoplasms.